曲妥珠单抗-Emtansine偶联物新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP30527CAS号：1018448-65-1纯度：98%

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CAS号	1018448-65-1	货号	BCP30527
中文名	曲妥珠单抗-Emtansine偶联物
英文名	Trastuzumab emtansine
中文别名	ado-曲妥珠单抗emtansine；曲妥珠单抗-美坦新偶联物;
英文别名	Ado-trastuzumab emtansine；Kadcyla; trastuzumab-DM1; trastuzumab-MCC-DM1; trastuzumab-MCC-DM1 antibody-drug conjugate; T-DM1; PRO132365;
SMILES
化学名称
分子式		分子量	148.5 kg/mol
纯度	98%	配送	惯例下常温包邮
产品描述	Trastuzumab emtansine is an antibody-drug conjugate (ADC) consisting of the recombinant anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab conjugated to the maytansinoid DM1 via a nonreducible thioether linkage (MCC) with potential antineoplastic activity. The trastuzumab moiety of this ADC binds to HER2 on tumor cell surface surfaces; upon internalization, the DM1 moiety is released and binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that overexpress HER2. Linkage of antibody and drug through a nonreducible linker has been reported to contribute to the improved efficacy and reduced toxicity of this ADC compared to similar ADCs constructed with reducible linkers. Check for active clinical trials or closed clinical trials using this agent.

曲妥珠单抗-Emtansine偶联物 新