S0859
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1019331-10-2 | Cat. No. | BCP06882 |
| Name | S0859 | ||
| Synonyms | S 0859;S-0859; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C29H24ClN3O3S | M. Wt | 530.04 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | S0859 is a selective, high-affinity generic NBC inhibitor, potentially important for probing the transporter's functional role in heart and other tissues. S0859 reversibly inhibited NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). In HEPES-buffered superfusates, NHE-mediated pH(i) recovery was unaffected by 30 microM S0859. With CO(2)/HCO(3) (-) buffer, pH(i) recovery from intracellular alkalosis (mediated by Cl(-)/HCO(3) (-) and Cl(-)/OH(-) exchange) was also unaffected. | ||
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