NSC-12
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CAS No. | 102586-30-1 | Cat. No. | BCP24324 |
Name | NSC-12 | ||
Synonyms | NSC 12; NSC12; NSC 172285; NSC-172285; NSC172285; | ||
SMILES | C[C@@]12[C@](CC[C@]2([H])[C@@H](O)CC(C(F)(F)F)(O)C(F)(F)F)([H])[C@@]3([H])[C@]([C@@]4(C(C[C@@H](O)CC4)=CC3)C)([H])CC1 | ||
Chemical Name | |||
Formula | C24H34F6O3 | M. Wt | 484.52 |
Purity | 98% | Storage | Store at 4-8°C |
Description | NSC-12, also known as NSC 172285, is an extracellular FGF trap with significant implications in cancer therapy. NSC12 inhibited the proliferation of different FGF-dependent tumour cell lines, but had no inhibitory effect on FGF-independent tumour cells expressing a constitutively active FGFR1. In vivo, NSC12 was shown to inhibit FGFR phosphorylation, angiogenesis and primary and metastatic tumour growth of FGF-dependent human and mouse cancer cells. Importantly, there was no systemic toxic effect. |
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