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NSC-12 Chemical Structure

NSC-12

Data Sheet For research use only. Not for human use.
Cat. No. :BCP24324CAS No. :102586-30-1Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 102586-30-1 Cat. No. BCP24324
Name NSC-12
Synonyms NSC 12; NSC12; NSC 172285; NSC-172285; NSC172285;
SMILES C[C@@]12[C@](CC[C@]2([H])[C@@H](O)CC(C(F)(F)F)(O)C(F)(F)F)([H])[C@@]3([H])[C@]([C@@]4(C(C[C@@H](O)CC4)=CC3)C)([H])CC1
Chemical Name
Formula C24H34F6O3 M. Wt 484.52
Purity 98% Storage Store at 4-8°C
Description NSC-12, also known as NSC 172285, is an extracellular FGF trap with significant implications in cancer therapy. NSC12 inhibited the proliferation of different FGF-dependent tumour cell lines, but had no inhibitory effect on FGF-independent tumour cells expressing a constitutively active FGFR1. In vivo, NSC12 was shown to inhibit FGFR phosphorylation, angiogenesis and primary and metastatic tumour growth of FGF-dependent human and mouse cancer cells. Importantly, there was no systemic toxic effect.
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