GNE-490

参考资料仅供科学研究，不可用于个人用途。

货号：BCP21623CAS号：1033739-92-2纯度：98%

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CAS号	1033739-92-2	货号	BCP21623
中文名	GNE-490
英文名	GNE-490
中文别名
英文别名	GNE490;GNE 490;
SMILES	OC(C)(C)C1=CC2=C(S1)C(N3CCOCC3)=NC(C4=C(C)N=C(N)N=C4)=N2
化学名称
分子式	C18H22N6O2S	分子量	386.47
纯度	98%	配送	惯例下常温包邮
产品描述	GNE-490 is a highly selective pan-PI3K inhibitor that demonstrates selectivity over mTOR. It has good pharmacokinetic (PK) parameters and demonstrates knock down of pathway markers in vivo. Originally obtained via modification of compounds like GDC-0941, GNE-490 which have a significantly reduced potency mTOR while maintaining effective potency for PI3K substrates. IC50 values for PI3K family members are in the subnanomolar to low nanomolar range (-.28 to <20nm) while IC50 values for mTOR and other related tyrosine kinases are greater than 750 nM with most being greater than 1 uM or more, thus GNE-490 makes a good choice for examining PI3K related events separate from those mediated by mTOR.