Lefamulin New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP24164CAS No. ：1061337-51-6Purity：98%

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CAS No.	1061337-51-6	Cat. No.	BCP24164
Related Products	1350636-82-6（Lefamulin Acetate）
Name	Lefamulin
Synonyms	BC-3781;BC 3781;BC3781;
SMILES	CC1CCC23CCC(=O)C2C1(C(CC(C(C3C)O)(C)C=C)OC(=O)CSC4CCC(CC4O)N)C
Chemical Name
Formula	C27H43NO5S	M. Wt	493.7
Purity	98%	Storage	Store at 4-8°C
Description	Lefamulin is a semi-synthetic compound that inhibits the synthesis of bacterial protein, which is required for bacteria to grow. Lefamulin acts by binding to the peptidyl transferase center, or PTC, on the bacterial ribosome in such a way that it interferes with the interaction of protein production at two key sites known as the “A” site and the “P” site, resulting in the inhibition of bacterial proteins and the cessation of bacterial growth. Lefamulin’s binding occurs with high affinity, high specificity and at molecular sites that are different than other antibiotic classes. Lefamulin exhibited MIC50 and MIC90 values of 0.12 and 0.25 μg/ml, respectively, against the entire collection (n = 822). Similar results were obtained for lefamulin against each of the most common serotypes as well as against multidrug-resistant isolates and strains that are nonsusceptible to ceftriaxone or erythromycin. Lefamulin may be useful for the treatment of community-acquired respiratory tract infections.