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RO3280 Chemical Structure

RO3280

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP07189CAS No. ：1062243-51-9Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1062243-51-9 Cat. No. BCP07189
Name RO3280
Synonyms Ro5203280; Ro-5203280; Ro 5203280; RO5203280;
SMILES
Chemical Name
Formula C27H35F2N7O3 M. Wt 543.61
Purity 98% Storage Store at 4-8°C
Description Ro5203280 is a small-molecular PLK1 inhibitor that is structurally similar to BI2536, but with improved activity. R05203280 exhibits a high selectivity and shows a very low Kd (0.09 nmol/L) to PLK1 when compared with the 0.2 nmol/L Kd of BI2536. Ro5203280 also exhibits potent and broad activity in suppressing a large panel of 30 cell lines with IC50 as low as 6 nmol/L. Ro5203280 shows a high efficacy for suppressing nasopharyngeal carcinoma growth with low toxicity in mouse studies. It suppresse
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