TM 5275 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1103928-13-7 | Cat. No. | BCP30130 |
| Name | TM 5275 | ||
| Synonyms | TM-5275;TM5275; | ||
| SMILES | O=C(O)C1=CC(Cl)=CC=C1NC(COCC(N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)=O)=O | ||
| Chemical Name | |||
| Formula | C28H28ClN3O5 | M. Wt | 521.99 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | TM 5275 is selective, orally active inhibitor of plasminogen activator inhibitor-1 (PAI-1; IC50 value 6.95 µM in tissue plasminogen activator-dependent peptide hydrolysis essay) with antithrombotic benefits devoid of bleeding effect in rodents and nonhuman primates, and with impressive bioavailability.TM 5275 prolongs tPA retention and enhances plasmin generation on the vascular endothelial cell (VEC) surface as a result of PAI-1 inhibition. | ||
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