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Ivacaftor hydrate 结构式

Ivacaftor hydrate

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP14735CAS号 :1134822-07-3纯度:98%
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  • 基本信息与产品描述
CAS号 1134822-07-3 货号 BCP14735
中文名 Ivacaftor hydrate
英文名 Ivacaftor hydrate
中文别名
英文别名 VX-770 hydrate;VX 770 hydrate;VX770 hydrate;Kalydeco hydrate;
SMILES
化学名称
分子式 C24H30N2O4 分子量 410.51
纯度 98% 配送 惯例下常温包邮
产品描述 in vitro: In recombinant cells VX-770 increased CFTR channel open probability (P(o)) in both the F508del processing mutation and the G551D gating mutation. VX-770 also increased Cl(-) secretion in cultured human CF bronchial epithelia (HBE) carrying the G551D gating mutation on one allele and the F508del processing mutation on the other allele by approximately 10-fold, to approximately 50% of that observed in HBE isolated from individuals without CF. in vivo: At day 28, in the group of subjects who received 150 mg of VX-770, the median change in the nasal potential difference (in response to the administration of a chloride-free isoproterenol solution) from baseline was -3.5 mV (range, -8.3 to 0.5; P=0.02 for the within-subject comparison, P=0.13 vs. placebo), and the median change in the level of sweat chloride was -59.5 mmol per liter (range, -66.0 to -19.0; P=0.008 within-subject, P=0.02 vs. placebo). Toxicity: Six severe adverse events occurred in two subjects (diffuse macular rash
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