Saridegib hydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1169829-40-6 | Cat. No. | BCP21080 |
| Name | Saridegib hydrochloride | ||
| Synonyms | Saridegib HCl;IPI 926 hydrochloride;IPI 926; IPI-926; IPI926; Saridegib; Patidegip; | ||
| SMILES | CC1=C(C[C@@]2([H])[C@@]3([H])CC[C@@]4([H])[C@]2(C)CC[C@@H](NS(C)(=O)=O)C4)[C@@]3([H])CC[C@@]([C@@H]5C)(C1)O[C@@]6([H])[C@@]5([H])NC[C@@H](C)C6.Cl[H] | ||
| Chemical Name | |||
| Formula | C29H48N2O3S.HCl | M. Wt | 541.23 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Saridegib, also known as IPI-926, is an orally bioavailable, cyclopamine-derived (for structure comparison see Fig 1) inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specifically, Hedgehog pathway inhibitor IPI-926 binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligand to the cell surface receptor Patched (PTCH); inappropriate activation of Hh signaling and uncontrolled cellular proliferation may be associated with SMO mutations. | ||
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