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Combretastatin A4 Chemical Structure

Combretastatin A4

Data Sheet For research use only. Not for human use.
Cat. No. :BCP04204CAS No. :117048-59-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 117048-59-6 Cat. No. BCP04204
Name Combretastatin A4
Synonyms NSC-817373;NSC 817373;CRC 87-09;CA4DP;Combretastatin A-4;(Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol;CRC-87-09;
SMILES COC1=C(C=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)O
Chemical Name
Formula C18H20O5 M. Wt 316.35
Purity 98% Storage Store at 4-8°C
Description Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM,and an antitumor, antiangiogenic and antimetastatic agent.Combrestatin A4 is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. Combrestatin A4 was shown to inhibit tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma), and MCF-7 (breast cancer).
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