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TAK-441 Chemical Structure

TAK-441

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP20946CAS No. ：1186231-83-3Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1186231-83-3 Cat. No. BCP20946
Name TAK-441
Synonyms LM2094; TAK441; TAK 441;
SMILES O=C(C(N1C)=C(OCC(F)(F)F)C2=C1C=C(CC)N(CC(C3=CC=CC=C3)=O)C2=O)NC4CCN(C(CO)=O)CC4
Chemical Name
Formula C28H31F3N4O6 M. Wt 576.56
Purity 98% Storage Store at 4-8°C
Description TAK-441 is a potent inhibitor of Hedgehog (Hh) signaling pathway. TAK-441 showed activity to suppress transcription factor Gli1 mRNA expression in tumor-associated stromal tissue and inhibited tumor growth (treatment/control ratio, 3%) in a mouse medulloblastoma allograft model owing to the improved PK profile based on increased solubility. TAK-441 is currently in clinical trials for the treatment of advanced solid tumors.
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