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Atpenin A5 Chemical Structure

Atpenin A5

Data Sheet For research use only. Not for human use.
Cat. No. :BCP38457CAS No. :119509-24-9Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 119509-24-9 Cat. No. BCP38457
Name Atpenin A5
Synonyms Antibiotic FO-125A5;
SMILES CC(CC(C)C(=O)C1=C(C(=C(NC1=O)OC)OC)O)C(CCl)Cl
Chemical Name
Formula C15H21Cl2NO5 M. Wt 366.24
Purity 98% Storage Store at 4-8°C
Description Atpenin A5 is an inhibitor of SDHB, SDHC and SDHD. It is an antifungal antibiotic and an ubiquinone-binding site inhibitor of succinate dehydrogenase with IC50s of 12 nM for nematode and IC50s of 3.7 nM for mammalian mitochondria. Atpenin A5 is the most effective inhibitor against complex II from all the atpenins and has been shown to protect against cardiac-reperfusion injury in rat studies through the stimulation of mitochondrial KATP channels.
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