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Epacadostat Chemical Structure

Epacadostat

Data Sheet For research use only. Not for human use.
Cat. No. :BCP14546CAS No. :1204669-58-8Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1204669-58-8 Cat. No. BCP14546
Name Epacadostat
Synonyms INCB024360; INCB 024360; INCB-024360; INCB24360; INCB-24360; INCB 24360; IDO inhibitor 1;
SMILES BrC =C(F)C=CC(N/C(C2=N
Chemical Name
Formula C11H13BrFN7O4S M. Wt 438.23
Purity 98% Storage Store at 4-8°C
Description Epacadostat, also known as INCB024360 or INCB24360, is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase (IDO1), with potential immunomodulating and antineoplastic activities. INCB024360 targets and binds to IDO1, an enzyme responsible for the oxidation of tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, INCB024360 increases and restores the proliferation and activation of various immune cells, including dendritic cells (DCs), NK cells, and T-lymphocytes, as well as interferon (IFN) production, and a reduction in tumor-associated regulatory T cells (Tregs).
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