Loxoribine New
Data Sheet
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| CAS No. | 121288-39-9 | Cat. No. | BCP33260 |
| Name | Loxoribine | ||
| Synonyms | 7-Allyl-8-oxoguanosine;Loxoribina; Loxoribinum; RWJ-21757; RWJ 21757; RWJ21757; | ||
| SMILES | C=CCN1C2=C(N=C(NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | ||
| Chemical Name | |||
| Formula | C13H17N5O6 | M. Wt | 339.31 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Loxoribine is a guanine ribonucleotide derivative with immunostimulatory and immunomodulatory activity. Loxoribine undergoes facilitated transport across the plasma membrane into the cytoplasmic compartment of the cell and acts intracellularly, bypassing the biochemical steps involved in the membrane signal transduction pathway used by Ag or anti-IgM Abs to activate B cells. This agent activates the Toll-like receptor 7 (TLR7), a member of the TLR family of pathogen-associated molecular pattern recognition receptors thereby activating the innate immune system. | ||
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