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LDE225 Diphosphate Chemical Structure

LDE225 Diphosphate

Data Sheet For research use only. Not for human use.
Cat. No. :BCP11860CAS No. :1218778-77-8Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1218778-77-8 Cat. No. BCP11860
Name LDE225 Diphosphate
Synonyms NVP-LDE225; NVP-LDE-225; NVP LDE225;LDE-225;LDE 225;Erismodegib Diphosphate;Sonidegib phosphate;
SMILES
Chemical Name
Formula C26H32F3N3O11P2 M. Wt 681.49
Purity 98% Storage Store at 4-8°C
Description Sonidegib phosphate, the phosphate of sonidegib, also known as LDE225 or NPV-LDE225. Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) being developed as an anticancer agent by Novartis. It was approved by the FDA for treating basal cell carcinoma in July 2015. It has demonstrated significant efficacy against melanoma in vitro and in vivo. It also demonstrated efficacy in a mouse model of pancreatic cancer.
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