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GKT137831 Chemical Structure

GKT137831

Cat. No. :BCP14159CAS No. :1218942-37-0Purity:98%
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Synonyms GKT-137831;GKT 137831; GTK831; GTK-831; GTK 831;Setanaxib
CAS Number 1218942-37-0
Purity 98%
M. Wt 394.85
Formula C21H19ClN4O2
Storage Store at 4-8°C
GKT137831 is a novel and potent Nox4 inhibitor. GKT137831 reduced the increased leukocyte adherence to the vasculature, the pro-inflammatory phenotype of microglia and macroglia, the increased gene and protein expression of vascular endothelial growth factor, monocyte chemoattractant protein-1, and leukocyte adhesion molecules as well as vascular leakage. In all cultured cell types, GKT137831 reduced the hypoxia-induced increase in ROS levels and protein expression of various inflammatory mediators. GKT137831 may be potentially useful as a treatment for a variety of vision-threatening retinopathies.

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