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Torin 2 Chemical Structure

Torin 2

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02612CAS No. :1223001-51-1Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1223001-51-1 Cat. No. BCP02612
Name Torin 2
Synonyms Torin2; Torin-2;
SMILES
Chemical Name
Formula C24H15F3N4O M. Wt 432.4
Purity 98% Storage Store at 4-8°C
Description Torin 2 has the same binding mode as PI3Kγ, V882 serves as a hinge binding point and in the inner hydrophobic pocket Y867, D841 and D964 provide three more hydrogen bonds with aminopyridine side chain analogous to Y2225, D2195 and D2357 of mTOR.Torin 2 inhibits mTORC1, thus activates TFEB by promoting its nuclear translocation with EC50 of 1.666 mM.Torin 2(< 50 nM) causes a significant reduction in viability of both MZ-CRC-1 and TT cells. Torin 2 (100 nM) exerts a significant reduction of migration of both MZ-CRC-1 and TT cells.
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