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Larotrectinib Chemical Structure

Larotrectinib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP16262CAS No. :1223403-58-4Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1223403-58-4 Cat. No. BCP16262
Name Larotrectinib
Synonyms ARRY-470;ARRY 470;ARRY470;LOXO-101; LOXO-101; LOXO101;
SMILES C1CC(N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CCC(C4)O)C5=C(C=CC(=C5)F)F
Chemical Name
Formula C21H22F2N6O2 M. Wt 428.44
Purity 98% Storage Store at 4-8°C
Description Larotrectinib, also known as ARRY-470 and LOXO-101, is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC. LOXO-101 has IC50 values in the low nanomolar range for inhibition of all three TRK family members in binding and cellular assays, with 100x selectivity over other kinases, and has shown acceptable pharmaceutical properties and safety in nonclinical models. The TRK family of neurotrophin receptors, TRKA, TRKB, and TRKC (encoded by NTRK1, NTRK2, and NTRK3 genes, respectively) and their neurotrophin ligands regulate growth, differentiation and survival of neurons.
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