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Larotrectinib sulfate 结构式

硫酸拉罗替尼

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货号 :BCP24096CAS号 :1223405-08-0纯度:98%
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  • 基本信息与产品描述
CAS号 1223405-08-0 货号 BCP24096
中文名 硫酸拉罗替尼
英文名 Larotrectinib sulfate
中文别名 拉罗替尼硫酸盐;
英文别名 LOXO 101 sulfate;LOXO101 sulfate;LOXO-101 sulfate;
SMILES C1CC(N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CCC(C4)O)C5=C(C=CC(=C5)F)F.OS(=O)(=O)O
化学名称
分子式 C21H24F2N6O6S 分子量 526.51
纯度 98% 配送 惯例下常温包邮
产品描述 Larotrectinib Sulfate is the sulfate salt form of larotrectinib, an orally available, tropomyosin receptor kinase (Trk) inhibitor, with potential antineoplastic activity. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and Trk activation, which results in both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress Trk. Trk, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival.
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