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Mps1-in-2 Chemical Structure

Mps1-in-2

Data Sheet For research use only. Not for human use.
Cat. No. :BCP19164CAS No. :1228817-38-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1228817-38-6 Cat. No. BCP19164
Name Mps1-in-2
Synonyms
SMILES
Chemical Name
Formula C26H36N6O3 M. Wt 480.6
Purity 98% Storage Store at 4-8°C
Description Mps1-IN-2 inhibited Mps1 kinase activity with half-maximal inhibitory concentrations (IC50) of 3145 nM when screened at 1 μM ATP (apparent Km for ATP < 1 μM). Both compounds demonstrated greater than 1000-fold selectivity relative to the 352 member kinase panel with the major exceptions of Alk and Ltk for Mps1-IN-1 and Gak and Plk1 for Mps1-IN-2. The M602Q Mps1 mutant was 5 and 19-fold less sensitive to Mps1-IN-1 and Mps1-IN-2 respectively.
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