XE 991 dihydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 122955-13-9 | Cat. No. | BCP34697 |
| Name | XE 991 dihydrochloride | ||
| Synonyms | XE991 dihydrochloride;XE991 2HCl; XE 991 2HCl; XE-991 2HCl; | ||
| SMILES | O=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15.Cl.Cl | ||
| Chemical Name | |||
| Formula | C26H22Cl2N2O | M. Wt | 449.38 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | XE991 is a potent and selective blocker of KCNQ voltage-gated potassium channels. XE991 blocks KCNQ2+3/M-currents (IC50 = 0.6-0.98 μM) and KCNQ1 homomeric channels (IC50 = 0.75 μM) but is less potent against KCNQ1/minK channels (IC50 = 11.1 μM). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo. | ||
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