CHR-3996 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP44113CAS No. ：1235859-13-8Purity：98%

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CAS No.	1235859-13-8	Cat. No.	BCP44113
Name	CHR-3996
Synonyms	CHR3996;CHR 3996;
SMILES	C1C(CC2C1C2NCC3=NC4=C(C=C3)C=C(C=C4)F)C5=NC=C(C=N5)C(=O)NO
Chemical Name
Formula	C21H20FN5O2	M. Wt	393.41
Purity	98%	Storage	Store at 4-8°C
Description	CHR-3996 is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor CHR-3996 inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. This agent may upregulate HSP70 and downregulate anti-apoptotic Bcl-2 proteins more substantially than some first-generation HDAC inhibitors. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins.