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OTS514 S-isomer HCl Chemical Structure

OTS514 S-isomer HCl

Data Sheet For research use only. Not for human use.
Cat. No. :BCP28890CAS No. :1338545-92-8Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1338545-92-8 Cat. No. BCP28890
Name OTS514 S-isomer HCl
Synonyms OTS 514 S-isomer HCl; OTS-514 S-isomer HCl;
SMILES
Chemical Name
Formula C21H21ClN2O2S M. Wt 400.92
Purity 98% Storage Store at 4-8°C
Description OTS514 is a potent TOPK (T-LAK cell-originated protein kinase) inhibitor. OTS514 exhibits growth suppressive effect on small cell lung cancer. TS514 effectively suppressed growth of SCLC cell lines (IC50 ; 0.4 ~ 42.6 nM) and led to their apoptotic cell death. Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) activity, which was involved in stemness of CSC. Furthermore, OTS514 treatment reduced CD90-positive SCLC cells and showed higher cytotoxic effect against lung sphere-derived CSC-like SCLC cells.
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