Tyrphostin AG 490 New
Data Sheet
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| CAS No. | 134036-52-5 | Cat. No. | BCP21393 |
| Name | Tyrphostin AG 490 | ||
| Synonyms | AG-490;AG 490;AG490;Tyrphostin B42; | ||
| SMILES | C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N | ||
| Chemical Name | |||
| Formula | C17H14N2O3 | M. Wt | 294.3 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Tyrphostin AG490 is a selective inhibitor of EGF receptor tyrosine kinase with an IC50 values of 2 and 13.5 μM for EGFR and ErbB2 respectively. AG490 is also a JAK3/STAT, JAK3/AP-1 and JAK3/MAPK signaling pathway inhibitor and also blocks JAK3 autophosphorylation. AG-490 significantly inhibits the constitutive activation of Stat3 in MOPC, MPC11, and S194 cells, leading to dramatic dose-dependent apoptosis. AG-490 (100 μM) inhibits Akt phosphorylation, inhibits the activation of nuclear factor-κB, and causes the activation of GSK-3β, leading to the reduction of c-Myc. AG-490 (50 μM) can induce apoptosis of imatinib-resistant BaF3 cells expressing T315I and E255K mutants of Bcr-Abl. | ||
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