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Belizatinib 结构式

Belizatinib

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货号 :BCP29521CAS号 :1357920-84-3纯度:98%
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  • 基本信息与产品描述
CAS号 1357920-84-3 货号 BCP29521
中文名 Belizatinib
英文名 Belizatinib
中文别名
英文别名 TSR011; TSR011; TSR 011;
SMILES O=C(NC1=NC2=CC=C(CN3CCC(C(C)(O)C)CC3)C=C2N1[C@H]4CC[C@@H](C(NC(C)C)=O)CC4)C5=CC=C(F)C=C5
化学名称
分子式 C33H44FN5O3 分子量 577.73
纯度 98% 配送 惯例下常温包邮
产品描述 Belizatinib, also known as TSR-011, is an orally available inhibitor of both the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and the tropomyosin-related kinases (TRK) TRKA, TRKB, and TRKC, with potential antineoplastic activity. Upon administration, ALK/TRK inhibitor TSR-011 binds to and inhibits both ALK and TRK kinases. The inhibition leads to disruption of ALK- and TRK-mediated signaling and impedes tumor cell growth in ALK/TRK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; ALK dysregulation and gene rearrangements are associated with a series of tumors.
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