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NT113 Chemical Structure

NT113

Data Sheet For research use only. Not for human use.
Cat. No. :BCP29708CAS No. :1398833-56-1Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1398833-56-1 Cat. No. BCP29708
Name NT113
Synonyms NT-113; NT 113;
SMILES CN(C)CC=CC(=O)NC1=CC2=C(C=C1C#CC3C4C3COC4)N=CN=C2NC5=CC(=C(C=C5)F)Cl
Chemical Name
Formula C27H25ClFN5O2 M. Wt 505.97
Purity 98% Storage Store at 4-8°C
Description NT113 is a pan-ERBB inhibitor with high brain penetrance. NT113 inhibits the growth of glioblastoma xenografts with EGFR amplification. NT113 is active against GBM xenografts in which wild-type EGFR or EGFRvIII is highly expressed. NT113 has inhibitory activity, both in vivo and in vitro, on ERBB family member phosphorylation, as well as on the phosphorylation of downstream signaling mediator Akt. NT113 may be potentially useful in treating patients with GBM.
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