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Neomycin Chemical Structure

Neomycin

Data Sheet For research use only. Not for human use.
Cat. No. :BCP23590CAS No. :1404-04-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1404-04-2 Cat. No. BCP23590
Name Neomycin
Synonyms Framycetin;Soframycin;Fradiomycin B; Neomycin B;
SMILES Neomycin is a broad spectrum aminoglycoside antibiotic whose current use is limited to oral and topical administration. Neomycin has minimal oral absorption and its use has not been linked to instance
Chemical Name
Formula C23H46N6O13 M. Wt 614.64
Purity 98% Storage Store at 4-8°C
Description Neomycin is a broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is the minor component. Neomycin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, neomycin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.
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