Netarsudil mesylate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1422144-42-0 | Cat. No. | BCP24703 |
| Name | Netarsudil mesylate | ||
| Synonyms | AR-13324 mesylate;AR13324 mesylate;AR 13324 mesylate; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C30H35N3O9S2 | M. Wt | 645.74 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudil produced large reductions in IOP in rabbits and monkeys that were sustained for at least 24 h after once daily dosing, with transient, mild hyperemia observed as the only adverse effect. | ||
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