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PRI-724 Chemical Structure

PRI-724

Data Sheet For research use only. Not for human use.
Cat. No. :BCP32677CAS No. :1422253-38-0Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1422253-38-0 Cat. No. BCP32677
Related Products 780757-88-2(ICG-001) 847591-62-2(ICG-001)
Name PRI-724
Synonyms PRI724; PRI 724; C-82 prodrug; ICG-001 analog; ICG001 analog; ICG 001 analog;
SMILES CC1C2N(C(C(=O)N1CC3=CC=CC4=C3N=CC=C4)CC5=CC=C(C=C5)OP(=O)(O)O)C(=O)CN(N2C(=O)NCC6=CC=CC=C6)C
Chemical Name
Formula C33H35N6O7P M. Wt 658.65
Purity 98% Storage Store at 4-8°C
Description PRI-724 is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. Wnt signaling pathway inhibitor PRI-724 specifically inhibits the recruiting of beta-catenin with its coactivator CBP (the binding protein of the cAMP response element-binding protein CREB); together with other transcription factors beta-catenin/CBP binds to WRE (Wnt-responsive element) and activates transcription of a wide range of target genes of Wnt/beta-catenin signaling.
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