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Hexamethyleneamiloride Chemical Structure

Hexamethyleneamiloride

Data Sheet For research use only. Not for human use.
Cat. No. :BCP41883CAS No. :1428-95-1Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1428-95-1 Cat. No. BCP41883
Name Hexamethyleneamiloride
Synonyms 5-(N,N-Hexamethylene)amiloride; HMA;
SMILES C1CCCN(CC1)C2=NC(=C(N=C2Cl)C(=O)N=C(N)N)N
Chemical Name
Formula C12H18ClN7O M. Wt 311.77
Purity 98% Storage Store at 4-8°C
Description Hexamethyleneamiloride derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. It is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively.
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