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Elacridar 结构式

依克立达

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货号 :BCP05709CAS号 :143664-11-3纯度:98%
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  • 基本信息与产品描述
CAS号 143664-11-3 货号 BCP05709
中文名 依克立达
英文名 Elacridar
中文别名
英文别名 GF120918; GF-120918; GF 120918; GW 0918;GW-0918;GW0918; GG918;GG 918;GG-918; GF-120918; GF 120918;
SMILES
化学名称
分子式 C34H33N3O5 分子量 563.64
纯度 98% 配送 惯例下常温包邮
产品描述 Elacridar is a P-glycoprotein (P-gp) inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog plasma. GF120918A did not demonstrate potent inhibition of several human cytochrome P450 enzymes evaluated in vitro, with IC(50) values well above concentrations anticipated to be achieved in vivo. Together, these data confirm the utility of GF120918A as a tool P-glycoprotein inhibitor in preclinical species and offer additional guidance on preclinical dose regimens likely to produce P-glycoprotein-mediated effects.
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