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HDM201 Chemical Structure

HDM201

Data Sheet For research use only. Not for human use.
Cat. No. :BCP20814CAS No. :1448867-41-1Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1448867-41-1 Cat. No. BCP20814
Name HDM201
Synonyms Siremadlin; HDM 201; HDM-201; NVP-HDM201; NVP-HDM-201; NVP-HDM 201;
SMILES
Chemical Name
Formula C26H24Cl2N6O4 M. Wt 555.42
Purity 98% Storage Store at 4-8°C
Description HDM201 is an orally bioavailable human double minute 2 homolog (HDM2) inhibitor with potential antineoplastic activity. HDM2 inhibitor HDM201 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of both p53 signaling and p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger protein and negative regulator of the p53 pathway, is often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
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