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Pralatrexate Chemical Structure

Pralatrexate

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02025CAS No. :146464-95-1Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 146464-95-1 Cat. No. BCP02025
Name Pralatrexate
Synonyms Folotyn;10-Propargyl-10-deazaaminopterin;
SMILES
Chemical Name
Formula C23H23N7O5 M. Wt 477.47
Purity 98% Storage Store at 4-8°C
Description Pralatrexate is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intracellularly, this agent is highly polyglutamylated and competes for the folate binding site of DHFR, blocking tetrahydrofolate synthesis, which may result in depletion of nucleotide precursors; inhibition of DNA, RNA and protein synthesis; and apoptotic tumor cell death.
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