M8891 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1464842-09-8 | Cat. No. | BCP44098 |
| Name | M8891 | ||
| Synonyms | M-8891; M 8891; | ||
| SMILES | C1CN(C(=O)C1(C(=O)NCC2=CC(=CC(=C2)F)F)O)C3=CC4=C(C=C3)NC=C4 | ||
| Chemical Name | |||
| Formula | C20H17F2N3O3 | M. Wt | 385.36 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | M8891 is a potent and orally active methionine aminopeptidase 2 inhibitor with potential antiangiogenic and antineoplastic activities. Upon administration, MetAP2 inhibitor M8891 inhibits MetAP2 aminopeptidase activity and impairs protein synthesis, which may lead to a decrease in endothelial cell proliferation. Decreased proliferation of endothelial cells results in reductions of both angiogenesis and the growth and spread of solid tumors that are dependent on new blood vessel formation. MetAP2, a metallopeptidase, is involved in promoting protein synthesis and endothelial cell proliferation. | ||
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