DDD107498 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP31981CAS No. ：1469439-69-7Purity：98%

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CAS No.	1469439-69-7	Cat. No.	BCP31981
Name	DDD107498
Synonyms	DDD-107498; DDD 107498; DDD 498; DDD-498; DDD498; MMV121; MMV-121; MMV 121;
SMILES	C1CCN(C1)CCNC(=O)C2=CC(=NC3=C2C=C(C=C3)F)C4=CC=C(C=C4)CN5CCOCC5
Chemical Name
Formula	C27H31FN4O2	M. Wt	462.57
Purity	98%	Storage	Store at 4-8°C
Description	DDD107498, also known as DDD 498, is a multiple-stage antimalarial agent that inhibits protein synthesis. DDD107498 demonstrates potential to address a variety of clinical needs, including single-dose treatment, transmission blocking and chemoprotection. DDD107498 was developed from a screening programme against blood-stage malaria parasites; its molecular target has been identified as translation elongation factor 2 (eEF2), which is responsible for the GTP-dependent translocation of the ribosome along messenger RNA, and is essential for protein synthesis. This discovery of eEF2 as a viable antimalarial drug target opens up new possibilities for drug discovery.