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BI-1467335 结构式

BI-1467335

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货号 :BCP42731CAS号 :1478364-40-7纯度:98%
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  • 基本信息与产品描述
CAS号 1478364-40-7 货号 BCP42731
中文名 BI-1467335
英文名 BI-1467335
中文别名
英文别名 PXS-4728A; PXS4728A; PXS 4728A; BI1467335; BI 1467335;
SMILES CC(C)(C)NC(=O)C1=CC=C(C=C1)OCC(=CF)CN
化学名称
分子式 C15H21FN2O2 分子量 280.34
纯度 98% 配送 惯例下常温包邮
产品描述 BI-1467335 is a SSAO/VAP inhibitor potentially for the treatment of non-alcoholic steatohepatitis. VAP-1/SSAO contributes to the migration of neutrophils during acute lung inflammation, pulmonary infection and airway hyperractivity. Selective VAP-1/SSAO inhibition by PXS-4728A diminished leukocyte rolling and adherence induced by CXCL1/KC. Inhibition of VAP-1/SSAO also dampened the migration of neutrophils to the lungs in response to LPS, Klebsiella pneumoniae lung infection and CLP induced sepsis; whilst still allowing for normal neutrophil defense function, resulting in increased survival.
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