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CAS号 | 1478364-40-7 | 货号 | BCP42731 |
中文名 | BI-1467335 | ||
英文名 | BI-1467335 | ||
中文别名 | |||
英文别名 | PXS-4728A; PXS4728A; PXS 4728A; BI1467335; BI 1467335; | ||
SMILES | CC(C)(C)NC(=O)C1=CC=C(C=C1)OCC(=CF)CN | ||
化学名称 | |||
分子式 | C15H21FN2O2 | 分子量 | 280.34 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | BI-1467335 is a SSAO/VAP inhibitor potentially for the treatment of non-alcoholic steatohepatitis. VAP-1/SSAO contributes to the migration of neutrophils during acute lung inflammation, pulmonary infection and airway hyperractivity. Selective VAP-1/SSAO inhibition by PXS-4728A diminished leukocyte rolling and adherence induced by CXCL1/KC. Inhibition of VAP-1/SSAO also dampened the migration of neutrophils to the lungs in response to LPS, Klebsiella pneumoniae lung infection and CLP induced sepsis; whilst still allowing for normal neutrophil defense function, resulting in increased survival. |
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