COH000 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1534358-79-6 | Cat. No. | BCP31057 |
| Name | COH000 | ||
| Synonyms | COH-000; COH 000; | ||
| SMILES | O=C(C1=C(C(OC)=O)C2C=CC1([C@H](NC3=CC=CC=C3)CC4=CC=C(C)C=C4)O2)OC | ||
| Chemical Name | |||
| Formula | C25H25NO5 | M. Wt | 419.48 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | COH000 is a highly specific covalent allosteric SUMO E1 inhibitor with an IC50 of 0.2 μM for SUMOylation in vitro. COH000 targets a cryptic pocket distinct from the active site that is completely buried in all previous SUMO E1 structures and that COH000 binding to SUMO E1 is accompanied by a network of structural changes that altogether lock the enzyme in a previously unobserved inactive conformation. | ||
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