PFM01 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1558598-41-6 | Cat. No. | BCP42679 |
| Name | PFM01 | ||
| Synonyms | PFM-01; PFM 01;SML1735; | ||
| SMILES | CC(C)CN1C(=O)C(=CC2=CC=C(C=C2)O)SC1=S | ||
| Chemical Name | |||
| Formula | C14H15NO2S2 | M. Wt | 293.4 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PFM01 is a nuclease-specific MRE11 inhibitor. PFM01 targets MRE11 at a site near the dimer interface, distinct from that occupied by Mirin and PFM39 to allow disruption of the ssDNA-binding groove and selective inhibition against MRE11 endo-, but not exo-, nuclease activity. MRE11 within the MRE11-RAD50-NBS1 (MRN) complex acts in DNA double-strand break repair (DSBR), detection, and signaling. | ||
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