MTI-31 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP36715CAS号：1567915-38-1纯度：98%

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CAS号	1567915-38-1	货号	BCP36715
中文名	MTI-31
英文名	MTI-31
中文别名
英文别名	MTI31;MTI 31;LXI-15029;mTOR inhibitor-31;
SMILES	CC1COCCN1C2=NC3=C(C=CC(=N3)C4=CC(=CC=C4)C(=O)NC)C(=N2)N5C6CCC5COC6
化学名称
分子式	C26H30N6O3	分子量	474.57
纯度	98%	配送	惯例下常温包邮
产品描述	MTI-31 is a novel potent, selective mTORC1/mTORC2 inhibitor with Kd of 0.2 nM (mTOR), displays >5,000-fold selectivity over PIK3CA, PIK3CB and PIK3G; showed an IC50 value 39 nM in LANCE® assay of mTOR substrate phosphorylation; dose-dependently inhibits of both the mTORC1 substrates P-S6K1(T389), P-S6(S235/6), P-4EBP1(T70) and mTORC2 substrate P-AKT(S473) tumor cell lines harboring mTOR pathway dysregulation with IC50 of <0.12 uM; potently inhibited cell proliferation (IC50 <1 mmol/L) and in vivo tumor growth in multiple NSCLC models of EGFR/T790M, EML4-ALK, c-Met or KRAS (MED <10 mg/kg), also suppressed programmed death ligand 1 (PD-L1) in EGFR- and ALK-driven NSCLC, mediated in part by mTORC2/AKT/GSK3β-dependent proteasomal degradation.