PWT143 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP30431CAS No. ：1595129-71-7Purity：98%

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CAS No.	1595129-71-7	Cat. No.	BCP30431
Name	PWT143
Synonyms	PWT-143; PWT 143; ME-401; ME401; ME 401;
SMILES	CN(CC1)CCC1C2=C(CC(C)(C)NC3=NC(N4CCOCC4)=NC(N5C(S(C)(=O)=O)=NC6=C5C=CC=C6)=N3)C=CC=C2
Chemical Name
Formula	C31H40N8O3S	M. Wt	604.77
Purity	98%	Storage	Store at 4-8°C
Description	PWT143, also known as ME-401, is an orally bioavailable inhibitor of the delta isoform of phosphatidylinositide 3-kinase (PI3K), with potential antineoplastic activity. Upon oral administration, PI3K-delta inhibitor PWT143 selectively inhibits the delta isoform of PI3K and prevents the activation of the PI3K/AKT signaling pathway. This both decreases proliferation and induces cell death in PI3K-delta-overexpressing tumor cells. PI3K-delta plays a key role in the proliferation and survival of hematologic cancer cells. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.