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CFI-400945 fumarate Chemical Structure

CFI-400945 fumarate

Data Sheet For research use only. Not for human use.
Cat. No. :BCP25931CAS No. :1616420-30-4Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1616420-30-4 Cat. No. BCP25931
Name CFI-400945 fumarate
Synonyms Ocifisertib Fumarate;CFI400945; CFI 400945; CFI-400945;CFI400945 fumarate;
SMILES CC1CN(CC(O1)C)CC2=CC=C(C=C2)C=CC3=NNC4=C3C=CC(=C4)C5CC56C7=C(C=CC(=C7)OC)NC6=O.C(=CC(=O)O)C(=O)O
Chemical Name
Formula C37H38N4O7 M. Wt 650.72
Purity 98% Storage Store at 4-8°C
Description CFI-400945 fumarate is an orally available fumarate salt form of CFI-400945, a polo-like kinase 4 (PLK4) inhibitor with potential antineoplastic activity. Upon oral administration, polo-like kinase 4 inhibitor CFI-400945 selectively inhibits PLK4, which results in the disruption of mitosis and the induction of apoptosis. PLK4 inhibition also prevents cell division and inhibits proliferation of PLK4-overexpressing tumor cells. PLK4, a member of the polo family of serine/threonine kinases overexpressed in a variety of cancer cell types, plays a crucial role in the regulation of centriole duplication during the cell cycle.
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