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VLX600 Chemical Structure

VLX600

Data Sheet For research use only. Not for human use.
Cat. No. :BCP10627CAS No. :1622945-04-3Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1622945-04-3 Cat. No. BCP10627
Name VLX600
Synonyms VLX-600;VLX 600;
SMILES
Chemical Name
Formula C17H15N7 M. Wt 317.14
Purity 98% Storage Store at 4-8°C
Description VLX600 is a compound that shows selective cytotoxicity against quiescent cancer cells (IC50 = 1-10 µM) with selectivity for malignant cells. It induces necrosis in non-proliferating quiescent core cells in multicellular spheroids (MCs) formed from HCT116 colon cancer cells.VLX600 induces the expression of genes associated with hypoxia, glycolysis, and p53 signaling, stimulates autophagy, and triggers mitochondrial dysfunction in MCs. It displays antitumor activity against colon cancer xenografts with minimal systemic toxicity in mice.
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