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IDH-305 Chemical Structure

IDH-305

Data Sheet For research use only. Not for human use.
Cat. No. :BCP30411CAS No. :1628805-46-8Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1628805-46-8 Cat. No. BCP30411
Name IDH-305
Synonyms IDH 305; IDH305;
SMILES CC1=CC(=NC=C1C2=CC(=NC=C2)C(F)(F)F)C(C)NC3=NC=CC(=N3)N4C(COC4=O)C(C)F
Chemical Name
Formula C23H22F4N6O2 M. Wt 490.45
Purity 98% Storage Store at 4-8°C
Description IDH305 is an inhibitor of the citric acid cycle enzyme isocitrate dehydrogenase [NADP] cytoplasmic (isocitrate dehydrogenase 1; IDH1) with mutations at residue R132 (IDH1(R132)), with potential antineoplastic activity. Upon administration, IDH305 specifically inhibits IDH1(R132) mutant forms in the cytoplasm, which inhibits the formation of the oncometabolite 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1(R132)-expressing tumor cells.
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