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Tarloxotinib bromide Chemical Structure

Tarloxotinib bromide

Data Sheet For research use only. Not for human use.
Cat. No. :BCP32560CAS No. :1636180-98-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1636180-98-7 Cat. No. BCP32560
Name Tarloxotinib bromide
Synonyms PR-610;PR 610;PR610;TH-4000;TH 4000;TH4000;
SMILES CN1C=NC(=C1C[N+](C)(C)CC=CC(=O)NC2=NC=C3C(=C2)C(=NC=N3)NC4=CC(=C(C=C4)Cl)Br)[N+](=O)[O-].[Br-]
Chemical Name
Formula C24H24Br2ClN9O3 M. Wt 681.77
Purity 98% Storage Store at 4-8°C
Description Tarloxotinib bromide is a prodrug designed to selectively release a covalent (irreversible) EGFR tyrosine kinase inhibitor under severe hypoxia, a feature of many solid tumors. Tarloxotinib has the potential to effectively shut down aberrant EGFR signaling in a tumor-selective manner, thus potentially avoiding or reducing the systemic side effects associated with currently available EGFR tyrosine kinase inhibitors.
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