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Autophinib Chemical Structure

Autophinib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP25844CAS No. :1644443-47-9Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1644443-47-9 Cat. No. BCP25844
Name Autophinib
Synonyms
SMILES CC1=CC(=NN1)NC2=CC(=NC(=N2)OC3=CC=C(C=C3)[N+](=O)[O-])Cl
Chemical Name
Formula C14H11ClN6O3 M. Wt 346.73
Purity 98% Storage Store at 4-8°C
Description Autophinib is a potent, selective autophagy inhibitor with IC50s of 90 nM and 40 nM for starvation- and Rapamycin-induced autophagy, respectively. Autophinib is also an ATP competitive Vacuolar Protein Sorting 34 (VPS34) inhibitor with an IC50 of 19 nM. Autophinib inhibits autophagy induced by starvation or Rapamycin by targeting VPS34.
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