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ONO7475 Chemical Structure

ONO7475

Data Sheet For research use only. Not for human use.
Cat. No. :BCP33232CAS No. :1646839-59-9Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1646839-59-9 Cat. No. BCP33232
Name ONO7475
Synonyms ONO-7475; ONO 7475;
SMILES O=C(C1=CC2=C(N(C3=CC=CC=C3)C1=O)CCCC2=O)NC4=NC=C(OC5=CC=NC6=CC(OC)=C(OC)C=C56)C=C4
Chemical Name
Formula C32H26N4O6 M. Wt 562.58
Purity 98% Storage Store at 4-8°C
Description ONO-7475 is a potent, selective, and orally active novel Anexelekto/MER tyrosine kinase inhibitor with IC50 values of 0.7 nM and 1.0 nM, respectively. ONO-7475 sensitizes AXL-overexpressing EGFR-mutant NSCLC cells to the EGFR-TKIs, suppresses the emergence and maintenance of tolerant cells. ONO-7475 combines with Osimertinib (HY-15772) provides a bright promise for the study of EGFR-mutated non-small cell lung cancer (NSCLC).
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