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Alexidine dihydrochloride Chemical Structure

Alexidine dihydrochloride

Data Sheet For research use only. Not for human use.
Cat. No. :BCP30227CAS No. :1715-30-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1715-30-6 Cat. No. BCP30227
Name Alexidine dihydrochloride
Synonyms Alexidine 2HCl;
SMILES CCCCC(CC)CN=C(N)NC(=NCCCCCCN=C(N)NC(=NCC(CC)CCCC)N)N.Cl.Cl
Chemical Name
Formula C26H58Cl2N10 M. Wt 581.71
Purity 98% Storage Store at 4-8°C
Description Alexidine dihydrochloride is a potent and selective protein tyrosine phosphatase localized to the mitochondrion 1(PTPMT1) inhibitor with IC50 value of 1.08 μM in vitro. It induces apoptosis in cancer cell lines with ED50 value of 1.8-2.6 μM. It is an alkyl bis(biguanide) antiseptic and has been used in mouthwashes to eliminate plaque forming microorganisms. It binds to lipopolysaccharide and lipoteichoic acid, and inhibits fungal phospholipase B with IC50 value of 250 nM. It stimulates increased insulin secretion by isolated rat pancreatic islets and displays antitcancer properties in FaDu cells. It has antibacterial, antiplaque properties against streptococcus mutans, actinomyces naesludii and actinomyces ciscosus.
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