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CHIR-99021 trihydrochloride Chemical Structure

CHIR-99021 trihydrochloride

Data Sheet For research use only. Not for human use.
Cat. No. :BCP26069CAS No. :1782235-14-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1782235-14-6 Cat. No. BCP26069
Name CHIR-99021 trihydrochloride
Synonyms CT99021 trihydrochloride;CHIR-99021 3HCl; GSK 3 inhibitor XVI; GSK 3IXV;
SMILES CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N.Cl.Cl.Cl
Chemical Name
Formula M. Wt 574.72
Purity 98% Storage Store at 4-8°C
Description CHIR-99021 trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 trihydrochloride enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 trihydrochloride induces autophagy.
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