MZ 1 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP31482CAS No. ：1797406-69-9Purity：98%

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CAS No.	1797406-69-9	Cat. No.	BCP31482
Name	MZ 1
Synonyms	MZ1; MZ-1;
SMILES	CC1=C(C)SC2=C1C(C3=CC=C(Cl)C=C3)=N[C@@H](CC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](O)C4)C(NCC5=CC=C(C6=C(N=CS6)C)C=C5)=O)=O)=O)=O)C7=NN=C(C)N27
Chemical Name
Formula	C49H60ClN9O8S2	M. Wt	1002.64
Purity	98%	Storage	Store at 4-8°C
Description	MZ1 is a cell penetrant Proteolysis Targeting Chimera (PROTAC) compound based on (+)-JQ1 conjugated to a von Hippel-Lindau (VHL) ligand. Retains high affinity for BRD2, BRD3 and BRD4 bromodomains (Kd = 13-60 nM) but induces preferential degradation of BRD4 over BRD2 and BRD3 (DC50 values for degradation of BRD4 are 8 and 23 nM in H661 and H838 cells, respectively). Exhibits potent cytotoxicity and antiproliferative effects in AML cell lines (pEC50 = 7.6 in Mv4-11 cells). Negative control cis MZ 1 also available.