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BMS986205 Chemical Structure

BMS986205

Data Sheet For research use only. Not for human use.
Cat. No. :BCP20339CAS No. :1923833-60-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1923833-60-6 Cat. No. BCP20339
Name BMS986205
Synonyms BMS986205;BMS 986205; ONO-7701; ONO 7701; ONO7701; F-001287; F001287; F001287; Linrodostat;
SMILES CC(C1CCC(CC1)C2=C3C=C(C=CC3=NC=C2)F)C(=O)NC4=CC=C(C=C4)Cl
Chemical Name
Formula C24H24ClFN2O M. Wt 410.91
Purity 98% Storage Store at 4-8°C
Description BMS-986205 is a potent and selective, orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities. BMS-986205 specifically targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the amino acid tryptophan into the immunosuppressive metabolite kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, BMS-986205 restores and promotes the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T lymphocytes, and causes a reduction in tumor-associated regulatory T cells (Tregs).
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