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BMS-986205 Chemical Structure

BMS-986205

Cat. No. :BCP20339CAS No. :1923833-60-6Purity:98%
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Synonyms BMS986205;BMS 986205; ONO-7701; ONO 7701; ONO7701; F-001287; F001287; F001287; Linrodostat
CAS Number 1923833-60-6
Purity 98%
M. Wt 410.91
Formula C24H24ClFN2O
Storage Store at 4-8°C
BMS-986205 is a potent and selective, orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities. BMS-986205 specifically targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the amino acid tryptophan into the immunosuppressive metabolite kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, BMS-986205 restores and promotes the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T lymphocytes, and causes a reduction in tumor-associated regulatory T cells (Tregs).

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